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import win32api import win32con # http://stackoverflow.com/questions/531998/is-there-a-way-to-set-the-environment-path-programatically-in-c-on-windows win32api.SendMessage(win32con.HWND_BROADCAST, win32con.WM_SETTINGCHANGE, 0, "Environment") print("WM_SETTINGCHANGE \"Environment\" broadcasted to all windows.")