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ToothFairy2-CVPR is the official benchmark repository for the ToothFairy2 dataset, a large-scale, publicly available collection of CBCT scans with voxel-level 3D annotations for 42 maxillofacial structures, including teeth, jawbones, sinuses, and alveolar canals. This benchmark evaluates state-of-the-art segmentation methods—ranging from CNNs to transformers and Mamba-based models on maxillofacial anatomical regions, using the ToothFairy2 dataset for training and test. All benchmarked methods are implemented within the nnU-Net framework, with targeted architectures implemented by us in the benchmark_networks/nnunetv2/nets folder and their corresponding trainer classes in the benchmark_networks/nnunetv2/training/nnUNetTrainer directory.

To train models with nnU‑Net based architecture, organize your dataset according to the nnU‑Net dataset format, as specified in the official documentation here. Specifically, you need to:

1. Create dataset folder
   Create the nnUNet_raw, nnUNet_preprocessed and nnUNet_results folders, and set the corresponding environment variables:

export nnUNet_raw_data_base="<path to nnUNet_raw>"
export nnUNet_preprocessed="<path to nnUNet_preprocessed>"
export RESULTS_FOLDER="<path for trained models>"

2. File structure
   Place your data in:
   nnUNet_raw/DatasetXXX_ToothFairy2/
   ├── imagesTr/
   ├── labelsTr/
   └── [optional] imagesTs/
   
   The naming of the single dataset cases must be:

• Training images: caseID_0000.nii.gz
• Corresponding labels: caseID.nii.gz (same caseID)

3. Generate dataset.json
   In the dataset root folder, include a dataset.json file like. You can auto-generate it using:

python -m nnunetv2.dataset_conversion generate_dataset_json -o nnUNet_raw/DatasetXXX_ToothFairy2 

4. Plan and preprocess To verify the dataset format, compute dataset fingerprints, prepare preprocessed data for training, and generate plans files, run the following commands (you can find more details here):

nnUNetv2_plan_and_preprocess -d XXX --verify_dataset_integrity

Actually, we already provide our plans file in the nnUNetplans_files folder.

To train the different models on the ToothFairy2 dataset (replace XXX with your dataset ID), use the following commands (more details here):

# Standard nnUNet (3D full resolution)
nnUNetv2_train XXX 3d_fullres 0 -tr nnUNetTrainer -p nnUNetPlans

# ResEncL nnUNet version (3D full resolution)
nUNetv2_train XXX 3d_fullres 0 -tr nnUNetTrainer -p nnUNetResEncUNetL

# nnFormer (3D full resolution)
nnUNetv2_train XXX 3d_fullres 0 -tr nnUNetTrainerUMmabaBot -p nnUNetPlans

# SwinUMamba (2D)
nnUNetv2_train XXX 2d 0 -tr nnUNetTrainerSwinUMambaD -p nnUNetPlans

# VMamba (2D)
nnUNetv2_train XXX 2d 0 -tr nnUNetTrainerVmamba -p nnUNetPlans

# UMamba (3D full resolution)
nnUNetv2_train XXX 3d_fullres 0 -tr nnUNetTrainerUMmabaBot -p nnUNetPlans

# Training without left/right mirroring (substitute the {nnUNetTrainerName} with one of the trainer names above, and correspondent 2d/3d_fullres configuration)
srun nnUNetv2_train XXX 2d/3d_fullres 0 -tr {nnUNetTrainerName}_onlyMirror01 -p nnUNetPlans