numpy
diff --git a/numpy/_core/src/multiarray/nditer_pywrap.c b/numpy/_core/src/multiarray/nditer_pywrap.c
@@ -1676,6 +1676,9 @@ npyiter_multi_index_set(
         }
         for (idim = 0; idim < ndim; ++idim) {
             PyObject *v = PySequence_GetItem(value, idim);
+            if (v == NULL) {
+                return -1;
+            }
             multi_index[idim] = PyLong_AsLong(v);
             Py_DECREF(v);
             if (error_converting(multi_index[idim])) {

diff --git a/numpy/_core/tests/test_nditer.py b/numpy/_core/tests/test_nditer.py
@@ -3531,3 +3531,19 @@ def test_signature_methods(method):
 
     assert "self" in sig.parameters
     assert sig.parameters["self"].kind is inspect.Parameter.POSITIONAL_ONLY
+
+
+def test_nditer_multi_index_no_segfault():
+    class BadSequence:
+        def __len__(self):
+            return 2
+
+        def __getitem__(self, i):
+            if i == 1:
+                raise RuntimeError("intentional error")
+            return 0
+
+    arr = np.zeros((3, 4))
+    it = np.nditer(arr, flags=["multi_index"])
+    with pytest.raises(RuntimeError, match="intentional error"):
+        it.multi_index = BadSequence()