diff --git a/end_to_end_tests/functional_tests/generated_code_execution/test_path_parameters.py b/end_to_end_tests/functional_tests/generated_code_execution/test_path_parameters.py
@@ -0,0 +1,151 @@
+from unittest.mock import MagicMock
+
+import httpx
+import pytest
+
+from end_to_end_tests.functional_tests.helpers import (
+    with_generated_client_fixture,
+    with_generated_code_import,
+)
+
+
+@with_generated_client_fixture(
+"""
+paths:
+  "/items/{item_id}/details/{detail_id}":
+    get:
+      operationId: getItemDetail
+      parameters:
+        - name: item_id
+          in: path
+          required: true
+          schema:
+            type: string
+        - name: detail_id
+          in: path
+          required: true
+          schema:
+            type: string
+      responses:
+        "200":
+          description: Success
+          content:
+            application/json:
+              schema:
+                type: object
+                properties:
+                  id:
+                    type: string
+""")
+@with_generated_code_import(".api.default.get_item_detail.sync_detailed")
+@with_generated_code_import(".client.Client")
+class TestPathParameterEncoding:
+    """Test that path parameters are properly URL-encoded"""
+
+    def test_path_params_with_normal_chars_work(self, sync_detailed, Client):
+        """Test that normal alphanumeric path parameters still work correctly"""
+        mock_httpx_client = MagicMock(spec=httpx.Client)
+        mock_response = MagicMock(spec=httpx.Response)
+        mock_response.status_code = 200
+        mock_response.json.return_value = {"id": "test"}
+        mock_response.content = b'{"id": "test"}'
+        mock_response.headers = {}
+        mock_httpx_client.request.return_value = mock_response
+
+        client = Client(base_url="https://api.example.com")
+        client.set_httpx_client(mock_httpx_client)
+
+        sync_detailed(
+            item_id="item123",
+            detail_id="detail456",
+            client=client,
+        )
+
+        mock_httpx_client.request.assert_called_once()
+        call_kwargs = mock_httpx_client.request.call_args[1]
+
+        # Normal characters should remain unchanged
+        expected_url = "/items/item123/details/detail456"
+        assert call_kwargs["url"] == expected_url
+
+    def test_path_params_with_reserved_chars_are_encoded(self, sync_detailed, Client):
+        """Test that path parameters with reserved characters are properly URL-encoded"""
+        # Create a mock httpx client
+        mock_httpx_client = MagicMock(spec=httpx.Client)
+        mock_response = MagicMock(spec=httpx.Response)
+        mock_response.status_code = 200
+        mock_response.json.return_value = {"id": "test"}
+        mock_response.content = b'{"id": "test"}'
+        mock_response.headers = {}
+        mock_httpx_client.request.return_value = mock_response
+
+        # Create a client with the mock httpx client
+        client = Client(base_url="https://api.example.com")
+        client.set_httpx_client(mock_httpx_client)
+
+        # Call the endpoint with path parameters containing reserved characters
+        sync_detailed(
+            item_id="item/with/slashes",
+            detail_id="detail?with=query&chars",
+            client=client,
+        )
+
+        # Verify the request was made with properly encoded URL
+        mock_httpx_client.request.assert_called_once()
+        call_kwargs = mock_httpx_client.request.call_args[1]
+
+        # The URL should have encoded slashes and query characters
+        expected_url = "/items/item%2Fwith%2Fslashes/details/detail%3Fwith%3Dquery%26chars"
+        assert call_kwargs["url"] == expected_url
+
+    def test_path_params_with_spaces_are_encoded(self, sync_detailed, Client):
+        """Test that path parameters with spaces are properly URL-encoded"""
+        mock_httpx_client = MagicMock(spec=httpx.Client)
+        mock_response = MagicMock(spec=httpx.Response)
+        mock_response.status_code = 200
+        mock_response.json.return_value = {"id": "test"}
+        mock_response.content = b'{"id": "test"}'
+        mock_response.headers = {}
+        mock_httpx_client.request.return_value = mock_response
+
+        client = Client(base_url="https://api.example.com")
+        client.set_httpx_client(mock_httpx_client)
+
+        sync_detailed(
+            item_id="item with spaces",
+            detail_id="detail with spaces",
+            client=client,
+        )
+
+        mock_httpx_client.request.assert_called_once()
+        call_kwargs = mock_httpx_client.request.call_args[1]
+
+        # Spaces should be encoded as %20
+        expected_url = "/items/item%20with%20spaces/details/detail%20with%20spaces"
+        assert call_kwargs["url"] == expected_url
+
+    def test_path_params_with_hash_are_encoded(self, sync_detailed, Client):
+        """Test that path parameters with hash/fragment characters are properly URL-encoded"""
+        mock_httpx_client = MagicMock(spec=httpx.Client)
+        mock_response = MagicMock(spec=httpx.Response)
+        mock_response.status_code = 200
+        mock_response.json.return_value = {"id": "test"}
+        mock_response.content = b'{"id": "test"}'
+        mock_response.headers = {}
+        mock_httpx_client.request.return_value = mock_response
+
+        client = Client(base_url="https://api.example.com")
+        client.set_httpx_client(mock_httpx_client)
+
+        sync_detailed(
+            item_id="item#1",
+            detail_id="detail#id",
+            client=client,
+        )
+
+        mock_httpx_client.request.assert_called_once()
+        call_kwargs = mock_httpx_client.request.call_args[1]
+
+        # Hash should be encoded as %23
+        expected_url = "/items/item%231/details/detail%23id"
+        assert call_kwargs["url"] == expected_url
diff --git a/end_to_end_tests/golden-record/my_test_api_client/api/naming/hyphen_in_path.py b/end_to_end_tests/golden-record/my_test_api_client/api/naming/hyphen_in_path.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -13,7 +14,9 @@ def _get_kwargs(
 ) -> dict[str, Any]:
     _kwargs: dict[str, Any] = {
         "method": "get",
-        "url": f"/naming/{hyphen_in_path}",
+        "url": "/naming/{hyphen_in_path}".format(
+            hyphen_in_path=quote(str(hyphen_in_path), safe=""),
+        ),
     }
 
     return _kwargs

diff --git a/...record/my_test_api_client/api/parameter_references/get_parameter_references_path_param.py b/...record/my_test_api_client/api/parameter_references/get_parameter_references_path_param.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -34,7 +35,9 @@ def _get_kwargs(
 
     _kwargs: dict[str, Any] = {
         "method": "get",
-        "url": f"/parameter-references/{path_param}",
+        "url": "/parameter-references/{path_param}".format(
+            path_param=quote(str(path_param), safe=""),
+        ),
         "params": params,
         "cookies": cookies,
     }

diff --git a/...den-record/my_test_api_client/api/parameters/delete_common_parameters_overriding_param.py b/...den-record/my_test_api_client/api/parameters/delete_common_parameters_overriding_param.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -21,7 +22,9 @@ def _get_kwargs(
 
     _kwargs: dict[str, Any] = {
         "method": "delete",
-        "url": f"/common_parameters_overriding/{param_path}",
+        "url": "/common_parameters_overriding/{param_path}".format(
+            param_path=quote(str(param_path), safe=""),
+        ),
         "params": params,
     }
 

diff --git a/...golden-record/my_test_api_client/api/parameters/get_common_parameters_overriding_param.py b/...golden-record/my_test_api_client/api/parameters/get_common_parameters_overriding_param.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -21,7 +22,9 @@ def _get_kwargs(
 
     _kwargs: dict[str, Any] = {
         "method": "get",
-        "url": f"/common_parameters_overriding/{param_path}",
+        "url": "/common_parameters_overriding/{param_path}".format(
+            param_path=quote(str(param_path), safe=""),
+        ),
         "params": params,
     }
 

diff --git a/...golden-record/my_test_api_client/api/parameters/get_same_name_multiple_locations_param.py b/...golden-record/my_test_api_client/api/parameters/get_same_name_multiple_locations_param.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -31,7 +32,9 @@ def _get_kwargs(
 
     _kwargs: dict[str, Any] = {
         "method": "get",
-        "url": f"/same-name-multiple-locations/{param_path}",
+        "url": "/same-name-multiple-locations/{param_path}".format(
+            param_path=quote(str(param_path), safe=""),
+        ),
         "params": params,
         "cookies": cookies,
     }

diff --git a/end_to_end_tests/golden-record/my_test_api_client/api/parameters/multiple_path_parameters.py b/end_to_end_tests/golden-record/my_test_api_client/api/parameters/multiple_path_parameters.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any
+from urllib.parse import quote
 
 import httpx
 
@@ -16,7 +17,12 @@ def _get_kwargs(
 ) -> dict[str, Any]:
     _kwargs: dict[str, Any] = {
         "method": "get",
-        "url": f"/multiple-path-parameters/{param4}/something/{param2}/{param1}/{param3}",
+        "url": "/multiple-path-parameters/{param4}/something/{param2}/{param1}/{param3}".format(
+            param4=quote(str(param4), safe=""),
+            param2=quote(str(param2), safe=""),
+            param1=quote(str(param1), safe=""),
+            param3=quote(str(param3), safe=""),
+        ),
     }
 
     return _kwargs

diff --git a/...to_end_tests/test-3-1-golden-record/test_3_1_features_client/api/const/post_const_path.py b/...to_end_tests/test-3-1-golden-record/test_3_1_features_client/api/const/post_const_path.py
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any, Literal, cast
+from urllib.parse import quote
 
 import httpx
 
@@ -28,7 +29,9 @@ def _get_kwargs(
 
     _kwargs: dict[str, Any] = {
         "method": "post",
-        "url": f"/const/{path}",
+        "url": "/const/{path}".format(
+            path=quote(str(path), safe=""),
+        ),
         "params": params,
     }
 

diff --git a/openapi_python_client/templates/endpoint_module.py.jinja b/openapi_python_client/templates/endpoint_module.py.jinja
@@ -1,5 +1,6 @@
 from http import HTTPStatus
 from typing import Any, cast
+from urllib.parse import quote
 
 import httpx
 
@@ -31,7 +32,7 @@ def _get_kwargs(
         {% if endpoint.path_parameters %}
         "url": "{{ endpoint.path }}".format(
         {%- for parameter in endpoint.path_parameters -%}
-        {{parameter.python_name}}={{parameter.python_name}},
+        {{parameter.python_name}}=quote(str({{parameter.python_name}}), safe=""),
         {%- endfor -%}
         ),
         {% else %}