@@ -159,7 +159,7 @@ def test_upgrade_dependencies(self):
             if sys.platform == 'win32':
                 expect_exe = os.path.normcase(os.path.realpath(expect_exe))
 
-            def pip_cmd_checker(cmd):
+            def pip_cmd_checker(cmd, **kwargs):
                 cmd[0] = os.path.normcase(cmd[0])
                 self.assertEqual(
                     cmd,
@@ -175,7 +175,7 @@ def pip_cmd_checker(cmd):
                 )
 
             fake_context = builder.ensure_directories(fake_env_dir)
-            with patch('venv.subprocess.check_call', pip_cmd_checker):
+            with patch('venv.subprocess.check_output', pip_cmd_checker):
                 builder.upgrade_dependencies(fake_context)
 
     @requireVenvCreate
@@ -547,8 +547,8 @@ def nicer_error(self):
         try:
             yield
         except subprocess.CalledProcessError as exc:
-            out = exc.output.decode(errors="replace")
-            err = exc.stderr.decode(errors="replace")
+            out = (exc.output or b'').decode(errors="replace")
+            err = (exc.stderr or b'').decode(errors="replace")
             self.fail(
                 f"{exc}\n\n"
                 f"**Subprocess Output**\n{out}\n\n"
 
@@ -308,14 +308,25 @@ def setup_python(self, context):
                         shutil.copyfile(src, dst)
                         break
 
+    def _call_new_python(self, context, *py_args, **kwargs):
+        """Executes the newly created Python using safe-ish options"""
+        # gh-98251: We do not want to just use '-I' because that masks
+        # legitimate user preferences (such as not writing bytecode). All we
+        # really need is to ensure that the path variables do not overrule
+        # normal venv handling.
+        args = [context.env_exec_cmd, *py_args]
+        kwargs['env'] = env = os.environ.copy()
+        env['VIRTUAL_ENV'] = context.env_dir
+        env.pop('PYTHONHOME', None)
+        env.pop('PYTHONPATH', None)
+        kwargs['cwd'] = context.env_dir
+        kwargs['executable'] = context.env_exec_cmd
+        subprocess.check_output(args, **kwargs)
+
     def _setup_pip(self, context):
         """Installs or upgrades pip in a virtual environment"""
-        # We run ensurepip in isolated mode to avoid side effects from
-        # environment vars, the current directory and anything else
-        # intended for the global Python environment
-        cmd = [context.env_exec_cmd, '-Im', 'ensurepip', '--upgrade',
-                                                         '--default-pip']
-        subprocess.check_output(cmd, stderr=subprocess.STDOUT)
+        self._call_new_python(context, '-m', 'ensurepip', '--upgrade',
+                              '--default-pip', stderr=subprocess.STDOUT)
 
     def setup_scripts(self, context):
         """
@@ -414,9 +425,8 @@ def upgrade_dependencies(self, context):
         logger.debug(
             f'Upgrading {CORE_VENV_DEPS} packages in {context.bin_path}'
         )
-        cmd = [context.env_exec_cmd, '-m', 'pip', 'install', '--upgrade']
-        cmd.extend(CORE_VENV_DEPS)
-        subprocess.check_call(cmd)
+        self._call_new_python(context, '-m', 'pip', 'install', '--upgrade',
+                              *CORE_VENV_DEPS)
 
 
 def create(env_dir, system_site_packages=False, clear=False,
 
@@ -0,0 +1,2 @@
+Allow :mod:`venv` to pass along :envvar:`PYTHON*` variables to ``ensurepip`` and ``pip`` when
+they do not impact path resolution
Original file line number	Diff line number	Diff line change
@@ -0,0 +1,2 @@
	1	+ Allow :mod:`venv` to pass along :envvar:`PYTHON*` variables to ``ensurepip`` and ``pip`` when
	2	+ they do not impact path resolution