@@ -118,8 +118,9 @@ def test_second_profiler(self):
         pr = self.profilerclass()
         pr2 = self.profilerclass()
         pr.enable()
-        self.assertRaises(ValueError, pr2.enable)
-        pr.disable()
+        self.addCleanup(pr.disable)
+        msg = f"tool {sys.monitoring.PROFILER_ID} is already in use"
+        self.assertRaisesRegex(ValueError, msg, pr2.enable)
 
     def test_throw(self):
         """

diff --git a/Misc/NEWS.d/next/Library/2026-07-05-16-09-31.gh-issue-153068.huY9Jh.rst b/Misc/NEWS.d/next/Library/2026-07-05-16-09-31.gh-issue-153068.huY9Jh.rst
@@ -0,0 +1,2 @@
+Fix :meth:`!cProfile.Profile.enable` to no longer overwrite errors from
+:mod:`sys.monitoring`.
diff --git a/Modules/_lsprof.c b/Modules/_lsprof.c
@@ -821,7 +821,6 @@ _lsprof_Profiler_enable_impl(ProfilerObject *self, int subcalls,
                                           "use_tool_id", "is",
                                           self->tool_id, "cProfile");
     if (check == NULL) {
-        PyErr_Format(PyExc_ValueError, "Another profiling tool is already active");
         goto error;
     }
     Py_DECREF(check);
Original file line number	Diff line number	Diff line change
		@@ -0,0 +1,2 @@
		Fix :meth:`!cProfile.Profile.enable` to no longer overwrite errors from
		:mod:`sys.monitoring`.