diff --git a/.github/CONTRIBUTING.rst b/.github/CONTRIBUTING.rst
@@ -37,7 +37,7 @@ Setting things up
 
    .. code-block:: bash
 
-      $ pre-commit install
+      $ prek install -f
 
 Finding something to do
 =======================
@@ -100,7 +100,7 @@ Here's how to make a one-off code change.
 
      .. code-block:: bash
 
-        $ pre-commit run -a
+        $ prek run -a
 
    - To actually make the commit (this will trigger tests style & type checks automatically):
 

diff --git a/.github/copilot-instructions.md b/.github/copilot-instructions.md
@@ -32,7 +32,7 @@ The repository follows a standard structure for Python projects. Here are some k
 - Read the stability guide mentioned at docs/source/stability_policy.rst to understand if your changes
   are breaking or incompatible.
 - Try to make sure your code is asyncio-friendly and thread-safe.
-- Run `uv run pre-commit` to run pre-commit hooks before committing your changes, but after `git add`ing them.
+- Run `uv run prek` to run pre-commit hooks before committing your changes, but after `git add`ing them.
 - Make sure you always test your changes. Either update or write new tests in the `tests/` directory.
 
 ### Pull Requests:

diff --git a/.github/labeler.yml b/.github/labeler.yml
diff --git a/.github/workflows/labelling.yml b/.github/workflows/labelling.yml
diff --git a/.github/workflows/prek.yml b/.github/workflows/prek.yml
@@ -0,0 +1,26 @@
+name: Prek checks
+permissions:
+  contents: read  # Needed to see what files to run pre-commit on
+
+on:
+  pull_request:
+    branches:
+      - '**'  # Matches all branch names, for PRs
+  push:
+    branches:
+      - 'master'  # Run tests on master branch
+
+# Cancel any in-progress runs of this workflow for the same PR or branch when a new commit is pushed.
+concurrency:
+  group: ${{ github.workflow }}-${{ github.event.pull_request.number || github.ref }}
+  cancel-in-progress: true
+
+jobs:
+  prek:
+    name: prek
+    runs-on: ubuntu-slim
+    steps:
+      - uses: actions/checkout@de0fac2e4500dabe0009e67214ff5f5447ce83dd # v6.0.2
+        with:
+          persist-credentials: false
+      - uses: j178/prek-action@0bb87d7f00b0c99306c8bcb8b8beba1eb581c037 # v1.1.1
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
@@ -1,11 +1,3 @@
-ci:
-    autofix_prs: false
-    # We use Renovate to update this file now, but we can't disable automatic pre-commit updates
-    # when using the `pre-commit` GitHub Action, so we set the schedule to quarterly to avoid
-    # frequent updates.
-    autoupdate_schedule: quarterly
-    autoupdate_commit_msg: 'Bump `pre-commit` Hooks to Latest Versions'
-
 repos:
 -   repo: https://github.com/astral-sh/ruff-pre-commit
     rev: 'v0.15.5'
@@ -29,6 +21,7 @@ repos:
           - cachetools>=7.0.0,<8.0.0
           - aiolimiter~=1.1,<1.3
           - . # this basically does `pip install -e .`
+        priority: 10
 -   repo: https://github.com/pre-commit/mirrors-mypy
     rev: v1.19.1
     hooks:
@@ -46,6 +39,7 @@ repos:
           - cachetools>=7.0.0,<8.0.0
           - aiolimiter~=1.1,<1.3
           - . # this basically does `pip install -e .`
+        priority: 10
     - id: mypy
       name: mypy-examples
       files: ^examples/.*\.py$
@@ -58,3 +52,4 @@ repos:
         - APScheduler>=3.10.4,<3.12.0
         - cachetools>=7.0.0,<8.0.0
         - . # this basically does `pip install -e .`
+      priority: 10
diff --git a/README.rst b/README.rst
@@ -43,10 +43,6 @@
    :target: https://app.codacy.com/gh/python-telegram-bot/python-telegram-bot/dashboard
    :alt: Code quality: Codacy
 
-.. image:: https://results.pre-commit.ci/badge/github/python-telegram-bot/python-telegram-bot/master.svg
-   :target: https://results.pre-commit.ci/latest/github/python-telegram-bot/python-telegram-bot/master
-   :alt: pre-commit.ci status
-
 .. image:: https://img.shields.io/badge/code%20style-black-000000.svg
    :target: https://github.com/psf/black
    :alt: Code Style: Black

diff --git a/changes/unreleased/5142.h7G2mCUQ2PobeTyLNewpvx.toml b/changes/unreleased/5142.h7G2mCUQ2PobeTyLNewpvx.toml
@@ -0,0 +1,5 @@
+internal = "Replace `pre-commit` with `prek`"
+[[pull_requests]]
+uid = "5142"
+author_uids = ["harshil21"]
+closes_threads = ["5138"]
diff --git a/pyproject.toml b/pyproject.toml
@@ -132,7 +132,7 @@ docs = [
     "pydantic >= 2.12.0a1 ; python_version >= '3.14'"
 ]
 linting = [
-    "pre-commit",
+    "prek",
     "ruff==0.15.5",
     "mypy==1.18.2",
     "pylint==4.0.5"

diff --git a/uv.lock b/uv.lock