Lehner Lab

Software developed by members of the Lehner lab at the Centre for Genomic Regulation (CRG)

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canya canya Public

A hybrid neural network to predict nucleation propensity

Python 12 5
Stop_codon_readthrough Stop_codon_readthrough Public

Source code for computational analyses and to reproduce all figures in the following publication: Genome-scale quantification and prediction of drug-induced readthrough of pathogenic premature term…

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GPCR-MAPS GPCR-MAPS Public

This repository contains the code to reproduce the analyses presented in the publication "The molecular basis of G-protein coupled receptor signaling" by Taylor Mighell and Ben Lehner

Jupyter Notebook 2
ABA_receptor ABA_receptor Public

Forked from MaximilianStammnitz/ABA_receptor

Companion scripts for DMS data processing, dose-response curve fitting and figure reproduction ("The genetic architecture of an allosteric hormone receptor", Stammnitz & Lehner, biorXiv 2025)

R 1 1
domainome domainome Public

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DiMSum DiMSum Public

An error model and pipeline for analyzing deep mutational scanning (DMS) data and diagnosing common experimental pathologies

R 45 7

Repositories

Type Language Sort

MoCHI Public
Neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data

lehner-lab/MoCHI's past year of commit activity

Python 57 MIT 9 2 1 Updated Aug 13, 2026
allostery_pathogenicity Public

lehner-lab/allostery_pathogenicity's past year of commit activity

Promela 0 MIT 0 0 0 Updated Aug 10, 2026
fuzzy_specificity Public
Code for "A complete map of specificity encoding enables reprogramming of a protein interaction" by Taraneh Zarin, Cristina Hidalgo-Carcedo and Ben Lehner

lehner-lab/fuzzy_specificity's past year of commit activity

R 2 MIT 0 0 0 Updated Aug 7, 2026
Programmed_readthrough Public
Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs. Here we use deep mutational scanning to quantify ~1,400 sequence variants for each of the three examples of human readthrough in the genes AQP4, MAPK10 and OPRK1.

lehner-lab/Programmed_readthrough's past year of commit activity

0 MIT 0 0 0 Updated Jul 13, 2026
OpenSplice Public
This repository contains all code to reproduce the analyses and figures in the OpenSplice paper. OpenSplice quantifies the impact of >590,000 variants on the splicing of 608 human exons using massively parallel site-saturation mutagenesis in minigene constructs.

lehner-lab/OpenSplice's past year of commit activity

Jupyter Notebook 6 MIT 0 0 0 Updated May 27, 2026
TF-MAPS Public
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins.

lehner-lab/TF-MAPS's past year of commit activity

R 1 MIT 0 0 0 Updated May 11, 2026
PDZ_homologs Public

lehner-lab/PDZ_homologs's past year of commit activity

HTML 2 MIT 0 0 0 Updated Feb 20, 2026
pdzextms Public
Source code for analyses and to reproduce all figures in the following publication: The effects of PDZ domain extensions on energies, energetic couplings and allostery (Hidalgo-Carcedo C & Faure AJ et al., 2023)

lehner-lab/pdzextms's past year of commit activity

R 0 MIT 0 0 0 Updated Jan 29, 2026
pdzext Public
Allosteric and Energetic Remodeling by Protein Domain Extensions

lehner-lab/pdzext's past year of commit activity

R 0 MIT 0 0 0 Updated Jan 28, 2026
ABA_receptor Public Forked from MaximilianStammnitz/ABA_receptor
Companion scripts for DMS data processing, dose-response curve fitting and figure reproduction ("The genetic architecture of an allosteric hormone receptor", Stammnitz & Lehner, biorXiv 2025)

lehner-lab/ABA_receptor's past year of commit activity

R 1 2 0 0 Updated Nov 19, 2025