python
@@ -2472,6 +2472,48 @@ def f():
         self.assertNotIsSubclass(types.FunctionType, P)
         self.assertNotIsInstance(f, P)
 
+    def test_runtime_checkable_generic_non_protocol(self):
+        # Make sure this doesn't raise AttributeError
+        with self.assertRaisesRegex(
+            TypeError,
+            "@runtime_checkable can be only applied to protocol classes",
+        ):
+            @runtime_checkable
+            class Foo[T]: ...
+
+    def test_runtime_checkable_generic(self):
+        @runtime_checkable
+        class Foo[T](Protocol):
+            def meth(self) -> T: ...
+
+        class Impl:
+            def meth(self) -> int: ...
+
+        self.assertIsSubclass(Impl, Foo)
+
+        class NotImpl:
+            def method(self) -> int: ...
+
+        self.assertNotIsSubclass(NotImpl, Foo)
+
+    def test_pep695_generics_can_be_runtime_checkable(self):
+        @runtime_checkable
+        class HasX(Protocol):
+            x: int
+
+        class Bar[T]:
+            x: T
+            def __init__(self, x):
+                self.x = x
+
+        class Capybara[T]:
+            y: str
+            def __init__(self, y):
+                self.y = y
+
+        self.assertIsInstance(Bar(1), HasX)
+        self.assertNotIsInstance(Capybara('a'), HasX)
+
     def test_everything_implements_empty_protocol(self):
         @runtime_checkable
         class Empty(Protocol):

@@ -1894,7 +1894,7 @@ def _proto_hook(other):
                     annotations = getattr(base, '__annotations__', {})
                     if (isinstance(annotations, collections.abc.Mapping) and
                             attr in annotations and
-                            issubclass(other, Generic) and other._is_protocol):
+                            issubclass(other, Generic) and getattr(other, '_is_protocol', False)):
                         break
                 else:
                     return NotImplemented
@@ -1912,7 +1912,7 @@ def _proto_hook(other):
             if not (base in (object, Generic) or
                     base.__module__ in _PROTO_ALLOWLIST and
                     base.__name__ in _PROTO_ALLOWLIST[base.__module__] or
-                    issubclass(base, Generic) and base._is_protocol):
+                    issubclass(base, Generic) and getattr(base, '_is_protocol', False)):
                 raise TypeError('Protocols can only inherit from other'
                                 ' protocols, got %r' % base)
         if cls.__init__ is Protocol.__init__:
@@ -2059,7 +2059,7 @@ def close(self): ...
     Warning: this will check only the presence of the required methods,
     not their type signatures!
     """
-    if not issubclass(cls, Generic) or not cls._is_protocol:
+    if not issubclass(cls, Generic) or not getattr(cls, '_is_protocol', False):
         raise TypeError('@runtime_checkable can be only applied to protocol classes,'
                         ' got %r' % cls)
     cls._is_runtime_protocol = True

diff --git a/Misc/NEWS.d/next/Library/2023-05-25-08-50-47.gh-issue-104935.-rm1BR.rst b/Misc/NEWS.d/next/Library/2023-05-25-08-50-47.gh-issue-104935.-rm1BR.rst
@@ -0,0 +1,3 @@
+Fix bugs with the interaction between :func:`typing.runtime_checkable` and
+:class:`typing.Generic` that were introduced by the :pep:`695`
+implementation. Patch by Jelle Zijlstra.