diff --git a/Doc/whatsnew/3.12.rst b/Doc/whatsnew/3.12.rst
@@ -1895,6 +1895,15 @@ Changes in the Python API
   * Mixing tabs and spaces as indentation in the same file is not supported anymore and will
     raise a :exc:`TabError`.
 
+* The :mod:`threading` module now expects the :mod:`!_thread` module to have
+  an ``_is_main_interpreter`` attribute.  It is a function with no
+  arguments that returns ``True`` if the current interpreter is the
+  main interpreter.
+
+  Any library or application that provides a custom ``_thread`` module
+  should provide ``_is_main_interpreter()``.
+  (See :gh:`112826`.)
+
 Build Changes
 =============
 

diff --git a/Lib/test/test_threading.py b/Lib/test/test_threading.py
@@ -1827,6 +1827,34 @@ def test__all__(self):
         support.check__all__(self, threading, ('threading', '_thread'),
                              extra=extra, not_exported=not_exported)
 
+    @requires_subprocess()
+    def test_gh112826_missing__thread__is_main_interpreter(self):
+        with os_helper.temp_dir() as tempdir:
+            modname = '_thread_fake'
+            import os.path
+            filename = os.path.join(tempdir, modname + '.py')
+            with open(filename, 'w') as outfile:
+                outfile.write("""if True:
+                    import _thread
+                    globals().update(vars(_thread))
+                    del _is_main_interpreter
+                    """)
+
+            expected_output = b'success!'
+            _, out, err = assert_python_ok("-c", f"""if True:
+                import sys
+                sys.path.insert(0, {tempdir!r})
+                import {modname}
+                sys.modules['_thread'] = {modname}
+                del sys.modules[{modname!r}]
+
+                import threading
+                print({expected_output.decode('utf-8')!r}, end='')
+                """)
+
+            self.assertEqual(out, expected_output)
+            self.assertEqual(err, b'')
+
 
 class InterruptMainTests(unittest.TestCase):
     def check_interrupt_main_with_signal_handler(self, signum):

diff --git a/Lib/threading.py b/Lib/threading.py
@@ -37,7 +37,20 @@
 _allocate_lock = _thread.allocate_lock
 _set_sentinel = _thread._set_sentinel
 get_ident = _thread.get_ident
-_is_main_interpreter = _thread._is_main_interpreter
+try:
+    _is_main_interpreter = _thread._is_main_interpreter
+except AttributeError:
+    # See https://github.com/python/cpython/issues/112826.
+    # We can pretend a subinterpreter is the main interpreter for the
+    # sake of _shutdown(), since that only means we do not wait for the
+    # subinterpreter's threads to finish.  Instead, they will be stopped
+    # later by the mechanism we use for daemon threads.  The likelihood
+    # of this case is small because rarely will the _thread module be
+    # replaced by a module without _is_main_interpreter().
+    # Furthermore, this is all irrelevant in applications
+    # that do not use subinterpreters.
+    def _is_main_interpreter():
+        return True
 try:
     get_native_id = _thread.get_native_id
     _HAVE_THREAD_NATIVE_ID = True